Riverdale's Nankeen Lily (Nano)
Nano is the son of Lily of Riverdale and Riverdale's Waldo.
​
Genetics: Lily and Waldo each carry 1 copy of Factor XII, variant 1 and variant 2.
​
Punnett square calculator results for offspring would be:
25% chance for AA
50% chance for Aa
25% chance for aa
​
Factor XII Deficiency, also known as Hageman trait, is an asymptomatic blood factor deficiency. While it does not cause an abnormal tendency to bleed, it can be observed as prolonged blood clotting times during certain laboratory screening tests and -- may be clinically useful in thrombosis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851158/
​
It should be noted that studies in animals, including non-human primates, have demonstrated that FXII has an essential role in pathological thrombus formation with no role in haemostasis. This finding offers the potential to develop a next-generation antithrombotic therapeutic strategy that would carry no bleeding risk and also have implications for inflammatory diseases.
https://onlinelibrary.wiley.com/doi/full/10.1111/joim.12430
​
Inhibiting thrombosis without generating bleeding risks is a major challenge in medicine. A promising solution may be the inhibition of coagulation factor XII (FXII), because its knock-out or inhibition in animals reduced thrombosis without causing abnormal bleeding. https://www.nature.com/articles/s41467-020-17648-w
